Disrupted sleep may predict Alzheimer's risk

Brain scan

Amyloid is a protein that can fold and form into plaques while tau is a protein that forms into tangles. However, the researchers also stated that not all participants involved in the study had spinal fluid abnormalities.

Amyloid plaques develop in parts of the brain that play a role in visual recognition and memory, causing symptoms of the disorder.

Scientists from the Britain's Medical Research Council Laboratory of Molecular Biology have for the first time, clearly pictured what the deposits typically seen in a person with Alzheimer's disease look like.

The study, published in the journal Neurology, followed and surveyed 101 subjects with an average age of 63.

There's evidence that amyloid plaques disrupt slow-wave sleep, the authors wrote, which is "important for feeling refreshed".

Worldwide, about 50 million people live with dementia - the most common type being Alzheimer's disease.

This is because they had either a parent with the disease or being a carrier of a gene that increases the risk for Alzheimer's disease called apolipoprotein E (APOE).

"This study and others in the field suggest that sleep may be a modifiable risk factor for Alzheimer's disease", said senior researcher Barbara Bendlin.

Tangles are created by damaged tau, a protein responsible for cell stability and structure.

Bethanie Mattek-Sands screams for help after horrific Wimbledon injury
Cirstea, who had dropped the first set 4-6 but took the second 7-6 (4), was declared the victor of the second round match. Just a devastating scene at Wimbledon as Bethanie Mattek-Sands goes down with an injury.

Those who reported worse sleep quality, more sleep problems and daytime sleepiness had more biological markers for Alzheimer's disease in their spinal fluid. This could explain why people with more Alzheimer's markers were more likely to report poor sleep, they added.

"Overall, this study confirms the relationship between early Alzheimer's disease and sleep disturbance", Ju said, "and (it) expands - in terms of both time and symptoms - the window in which sleep-wake problems can be assessed for and treated, with the hope of reducing the risk of dementia due to Alzheimer's disease".

Dr Doug Brown, director of research at the charity Alzheimer's Society, said: "This study adds to previous evidence that poor quality sleep may be associated with signs of Alzheimer's".

Bendlin said it's important to identify modifiable risk factors for Alzheimer's because delaying Alzheimer's disease in people by as little as five years could reduce the number of cases in the next 30 years by almost 6 million and save $367 billion in health care costs.

While there's no shortage of research examining how abnormal tau and amyloid beta proteins function, it's been unclear just how much artificial samples assembled in the lab differ from the structures that form in the lab.

One limitation of the study was that sleep problems were self-reported.

For example, there was no association seen between people who had sleep apnea and markers for Alzheimer's in their spinal fluid.

Finding out what causes Alzheimer's could be critical to stopping the disease as early as possible, before irreversible damage has been done.


  • Illinois House Delays Budget Session Amid Hazardous Materials Lockdown

    Illinois House Delays Budget Session Amid Hazardous Materials Lockdown

    The Capitol was not being evacuated, but people were kept from entering the building, the State Journal-Register . He did not have further details, but multiple media outlets on site reported the person arrested is female.
    Washington calls on Russian Federation  to work with United States  in Syria

    Washington calls on Russian Federation to work with United States in Syria

    Trump and Putin are expected to discuss a range of policy disagreements, including Syria and the ongoing crisis in Ukraine. Assad's forces have been widely held responsible for the attack.
    Samsung to invest $18bn in chips

    Samsung to invest $18bn in chips

    The company will also add a production line to its NAND factory in Xi'an, China to meet the demand for data storage chips. In the proposed 37 trillion won, Samsung vowed a 30 trillion won investment for expanding semiconductor facilities.
  • Chris Gayle to make T-20 comeback against India

    Chris Gayle to make T-20 comeback against India

    As per latest Pitch report at Sabina park, Kingston Stadium states more clearly sounds like a batting pitch. Conditions: It's quite hot out but there is a cool breeze flowing across the iconic venue .
    India ready for Sri Lanka

    India ready for Sri Lanka

    Dilani Manodara and Shashikala Siriwardene looked to be on their way of forming a partnership as strong as Raj and Sharma. Barring Chamari Atapattu, their batters have failed to impress, and bowlers lack bite in the Sri Lankan attack.
    Ministers braced for possible Donald Trump visit to the UK

    Ministers braced for possible Donald Trump visit to the UK

    The PM extended the invitation to the US President during a trip to Washington in January but the date has never been announced. In a speech on Saturday Mr Trump called CNN "garbage journalism".
  • Heat officially waive Chris Bosh, announce his number will be retired

    He was first sidelined by blood clots shortly after competing in the 2015 All-Star game and missed the balance of that season. Bosh was with the Heat for six seasons and helped take the Heat to two championships in 2012 and 2013.
    Trump, Merkel To Meet Ahead Of Summit Amid Differences On Climate, Trade

    Trump, Merkel To Meet Ahead Of Summit Amid Differences On Climate, Trade

    German chancellor Angela Merkel was predicting more disputes in remarks in advance of the G20 summit in her country. On Monday, Trump said of his call with King Salman, "Interesting things are happening!" but did not elaborate.
    Pacquiao loses belt to Horn in unanimous decision

    Pacquiao loses belt to Horn in unanimous decision

    Horn, a former high school substitute teacher, was not overawed by the occasion at all. Horn, 29, surpassed nearly every expectation that had been placed on him.
  • PM Modi and Xi will not meet at G20 Summit

    PM Modi and Xi will not meet at G20 Summit

    The flashpoint is the contested border region of Doklam in Bhutan, which is claimed by China as part of its Donglang region. India has opposed China's road construction in Doklam, which is a disputed territory between Thimphu and Beijing .

    Gold Stuck Near 8-week Lows After Fed Minutes

    The Fed's holdings have surged five-fold since 2008, ballooning in size as the Fed bought Treasury and mortgage bonds. The amount of proceeds would start at $10 billion a month and increase until it reached $50 billion a month.
    Dalit leaders arrested during press conference in Lucknow

    Dalit leaders arrested during press conference in Lucknow

    Indian media said the woman was attacked with acid for the first time in 2011, then in 2013 and again in March this year. Earlier on March 23, the woman was allegedly forced to drink acid by two men on-board a train near here.


Latest news

Analyst Price Targets On Purplebricks Group (LON:PURP)
Shore Capital restated a house stock rating on shares of N Brown Group plc in a research report on Friday, May 12th. Citigroup Inc. reissued a "neutral" rating on shares of NEX Group PLC in a research report on Tuesday, May 9th.

Why critically-ill British baby can not be moved to Vatican
Mrs May said: "I'm sure the thoughts of all Members of the House are with the family and Charlie at this exceptionally hard time". The Pope had earlier said he was praying for Charlie's parents and was following the situation "with affection and commotion".

Jay-Z's '4:44: Album Goes Certified Platinum Within a Week
Among them, Snoop Dogg , who actually admitted that he pirated the album, eager to see what JAY-Z had to say on his tracks. That's impressive, considering that the album is now only available via stream and download from Tidal and Sprint .

Your guide to day three at Wimbledon
Watson was off to a flying start on Court Two, losing only eight points on her way to winning the opening set in just 19 minutes. However, again, it doesn't take much for there to be a momentum swing or for her to gain some more footing on the court. "...

U.S. soldier killed, two wounded in Afghanistan's Helmand province
Army's 1st Battalion, 36th Infantry Regiment, 1st Brigade Combat Team, 1st Armored Division, based at Fort Bliss , Texas. Now about 8,400 USA troops are in Afghanistan along with about 5,000 North Atlantic Treaty Organisation forces.

American Patriots Don't Criticize Trump to Foreigners, Most Republicans Believe
Trust in the US military, which is historically found to be high, was not polled. Meanwhile fifteen percent were "unsure" and eight percent named another country.

Consider more time for changing old notes, says SC
On March 10, it sought replies from the Centre and RBI on the plea against tweaking of rules on exchange of demonetised currency. As per the rule, if the people who couldn't depsit the old notes in banks could still do it till March 31, 2017 at RBI branches.

Qatar Given Extra 48-Hrs To Respond To Saudi Demands
Meanwhile, Qatar's Defense Minister Khalid al Attiyah said on Sunday country is ready to defend itself if necessary. The GCC comprises Saudi Arabia , the UAE, Bahrain, Qatar , Kuwait and Oman.

Asus ZenFone 4 Max launches in Russian Federation
We'll let you know the moment the Asus ZenFone 4 Max breaks out of Russian Federation into other countries in the near future. However, for those who would like a handset that lasts forever on a single charge, this will probably be more than enough.

Canada gives $10M, apology to former Guantanamo prisoner
The Supreme Court of Canada ruled in 2010 that the actions of federal officials who participated in USA interrogations of Mr. A spokesman for Public Safety Minister Ralph Goodale confirmed an ongoing court process, but wouldn't say anything further.

Where is the India-China standoff heading?
If its land grab is challenged, China tends to play the victim, including accusing the other side of making a unsafe provocation. Geng would not be drawn on whether the two could meet there, saying bilateral meetings for Xi at the summit were being arranged.

Financial Advisory Service Inc. Increases Position in Ford Motor Company (F)
The automaker said average transaction prices after sales incentives were $35,657, an increase of almost $400 per vehicle. The sale was disclosed in a filing with the Securities & Exchange Commission, which is available through this hyperlink .

Kanye West Splits With Jay Z's Tidal Over $3M
West's lawyer sent a letter to the company one month ago claiming the contract would be terminated because Tidal was in breach. Kanye West , who is a co-owner of Jay-Z's Tidal , has reportedly left the company following a dispute over an unpaid bonus.

Google celebrates 140 years of Wimbledon with a doodle
Andy Murray is fighting to retain the trophy, but after crashing out of the first round at Queen's he's not in the best of form.

France Pledges to Bolster African Antiterrorism Force
Macron told the summit that France would contribute $9 million to the new force as well as contributing 70 vehicles. The European Union already has pledged some 50 million euros ($57 million) in support of the new G5 force.

Other news