It belongs to a class of drugs called sodium-glucose cotransporter-2 inhibitors. Excessive urination can potentially cause dehydration and blood volume depletion in high-risk patients that exacerbates circulatory problems.
Data from 2 large clinical trials have confirmed that treatment of type 2 diabetes with canagliflozin (Invokana®, Invokamet®, and Invokamet XR®; Janssen Pharmaceuticals, Inc.) may lead to an increased risk of leg and foot amputations, according to a US Food and Drug Administration (FDA) Drug Safety Communication.
The FDA's decision follows a MedWatch safety alert from this time a year ago, which regulators issued after finding that patients in the Invokana arms of J&J's two cardiovascular outcomes studies for the med were about twice as likely to experience amputations than were those in the placebo groups. The agency is requiring new warnings, including a prominent "boxed warning", to be added to the canagliflozin drug labels to describe this risk. Canagliflozin lowers blood sugar by causing the kidneys to remove sugar from the body through the urine.
Most of the amputations were of toes or the middle of the foot, but some patients needed their entire foot or leg removed, sometimes even above the knee.
Russia, Saudi Arabia back extension of oil output cuts In addition, US oil production is rising very quickly and is now up more than 10 per cent since mid-2016 to 9.3 million bpd. Also, they hoped that additional producers would join them in cutting when the extension begins in June.
Patients taking canagliflozin should notify your health care professionals right away if you develop new pain or tenderness, sores or ulcers, or infections in your legs or feet. Before initiating canagliflozin therapy, health care professionals should consider factors that may predispose patients to the need for amputations, including a history of prior amputation, peripheral vascular disease, neuropathy and diabetic foot ulcers. Health care professionals are also urged to monitor patients who receive the drug for signs and symptoms and to discontinue the drug if complications occur.
People with diabetes are already at risk of having lower limbs amputated because of circulatory and nerve damage that the disease does over time.
A number of patients had to undergo more than one amputation, and some of those involved both limbs.
The study was focused on determining how canagliflozin affected the renal endpoints in adults with type 2 diabetes. Healthcare professionals and patients can report adverse effects related to canagliflozin and other medicines to the FDA MedWatch program.
It will feature a number of already popular Android applications as well as the addition of future ones. Since then, Google Assistant has become a standard feature for the newest Android Nougat smartphones.
The company reported $2.39 earnings per share (EPS) for the quarter, topping the consensus estimate of $2.34 by $0.05. The company had revenue of $149.60 million for the quarter, compared to analysts' expectations of $158.32 million.
What do you think about the hardware and design? HTC U11 also joins the IP67 Bandwagon and is thus dust and water resistant. Interestingly, the U11 is priced the same in the United States and Europe, that is $749 in the USA and 749 Euros in Europe.
The Western Wall, the holiest site of Jewish prayer, is located in part of the territory it captured in the 1967 Middle East War. Israel regards Jerusalem as its eternal and indivisible capital and wants all foreign countries to base their embassies there.
United said its participation in the second-tier tournament, in the current season, had proved financially positive. United captain Rooney agreed with Mourinho in that Tottenham had more motivation going into the game.
She attempted to bring something other than a smile to the "DWTS" ballroom for her second dance, but they weren't buying it. He's been exceptionally hard on Normani, but his request is simple-12 bars of uninterrupted Viennese Waltz in hold.
Earlier, the company has launched Redmi Note 4 in January & Redmi 4A in March which are selling like hotcakes. Within a week of launching its first ever Mi Home in India , Xiaomi today launched the new Redmi 4.
The Moto C range will sit under the Moto E range and will offer a no fills smartphone experience to the budget conscious consumer. Moto G5 comes with the 13MP rear camera and a LED flashlight which captures images exceptionally well even in the low light.
Romero said in a statement . "If they take action based on this executive order that harms our community, we will sue". It just directs the IRS and the health care system to exercise "maximum enforcement discretion" in levying penalties.
In his first few months in office, Trump has repeatedly pushed extremely regressive policies on women's health. Previously the policy only applied to family planning assistance provided by the State Department and USAID.
Trump promised to fund, train, and equip law enforcement agencies around the country as part of his promise to keep America safe. The week was established by Congress in 1962 and starts Monday with National Peace Officers Memorial Day.
Daredevil Golden Gate Bridge video prompts security review
Despite climbing the bridge - and trespassing near it - being completely illegal, Teatime still called his climb a "must-do". Locati said the bridge's security system was "not created to protect thrill-seekers from harming themselves".
Sharapova misses out on French Open wild card after doping
Maybe they should give a wild card to Lance Armstrong, too? 'Nobody can deprive her two titles she won here in Roland Garros. She has played three tournaments thanks to wild cards since her return from a 15-month drug ban last month.
Spurs roll over Rockets, into conference finals
San Antonio's defense has contained Golden State as the Warriors are only shooting 30 percent to start the game. David Lee will face his old Warriors team, while David West faces the Spurs , his former team.
Instagram Rips Off Snapchat, Again - This Time with Face Filters
Sound familiar? That's because it's a feature Snapchat is known for - and Instagram is, yet again, taking an idea from its rival. It looks more like what you can do on Snapchat - and it was probably the biggest advantage it had over Instagram , until now.
Lalu puts up brave front amid IT raids
Following the IT raids, Sushil Kumar Modi told the media in Patna that his stand was "vindicated". Lalu's younger son Tejashwi Yadav is the deputy chief minister of Bihar.
Warriors rally for 113-111 win after Spurs lose Leonard
This is the second straight Spurs-Warriors meeting where the Dubs have stormed back after getting jumped on early by San Antonio . It's bad , and we hope he gets back soon, but I think it's a huge stretch to imply that Pachulia had any ill-intentions here.